Pathways Associated with cancer development Pathway Name S-specific transcription in mitotic cell cycle G2/M-specific transcription in mitotic cell cycle "Cell Cycle, Mitotic" Cell Cycle Checkpoints Transcriptional activation of cell cycle inhibitor p21 G2-specific transcription in mitotic cell cycle ERK1 activation ERK activation ERK2 activation PKA-mediated activation of ERK2 Prolonged ERK activation events APC/C-mediated degradation of cell cycle proteins Signaling by EGFR Grb2 events in EGFR signaling Shc events in EGFR signaling EGFR downregulation Signalling to ERKs Signaling by VEGF Neurophilin interactions with VEGF and VEGFR VEGF ligand-receptor interactions Degradation of beta-catenin by the destruction complex VEGF binds to VEGFR leading to receptor dimerization Beta-catenin phosphorylation cascade ERK/MAPK targets Signalling to ERK5 ERKs are inactivated EGFR interacts with phospholipase C-gamma